Vaughn Miller will present his talk a second time for those who missed it, or may have been unable to attend due to time differences.
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On Friday February 19th, BIOCIUS will be one of the vendors at local C.A.C.O meeting in Foster City, CA. The Event will be held at the Foster City Crowne Plaza from 11 a.m. – 1:30 p.m. Stop by if you are in the area!
https://www.caco-ca.org/aspx/sfchemists.aspx
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BIOCIUS employees, Margaret Chute, Production Associate(furthest left in picture) and Marissa Mullane, Marketing Assistant(furthest right in picture) spent a long weekend in Rangeley, Maine playing in the New England Pond Hockey Festival.
Originally an all-male tournament, the New England Pond Hockey Tournament opened up a women’s division for the first time this year, and like most of the athletically active BIOCIUS employees, Margaret and Marissa were eager to spend a weekend facing off against old college rivals of Bowdoin College. Both Margaret and Marissa played hockey for Colby College in their college days, before working for BIOCIUS Life Sciences.
After three games on Saturday(two wins and a loss to Bowdoin), in just above zero degree weather, the Blueskis geared up for the championship game on Sunday. After another hard fought game, the BIOCIUS Bogart Blueskis came out on top and took the T
ournament title earning the first women’s spot on the championship trophy.
Colby, Bowdoin Rivalry
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The conference will be held January 23-27, 2010 at the Palm Springs Convention Center, in Palm Springs, CA. Be sure to stop by the BIOCIUS booth at ALA, # 368!
In addition to attending ALA, BIOCIUS Senior Field Applications Engineer, Maxine Jonas will be presenting a talk: “The RapidFire 300: An integrated, automated SPE-MS system for high-throughput ADME sample analysis” in the High-Throughput Technologies track in the session titled “Parallel Process Advances”. The talk will take place on Wednesday January 27th at 9:00 a.m.
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Mayr and Bojanic’s noteworthy recent article gives a descriptive history of HTS, starting with its origins and detailing the path through which it has evolved over the past decade and a half to encompass multiple steps such as the primary, counter, and validation screens that are currently familiar. The authors describe how researchers’ focus has shifted over time from a brute-force effort at simply increasing throughput to a more narrow approach geared toward achieving better data on fewer compounds by employing in silico tools, focused libraries, and fragment-based screens. They go on to forecast future alterations in the target classes of major interest as well as both the screen design and infrastructure used by companies to meet their pressing need to acquire high quality data on a large number of compounds rapidly and with minimal artifacts, such that those compounds with greatest promise of becoming viable drugs are identified as quickly and efficiently as possible. I, for one, am certainly looking forward to discovering how accurate the authors’ predictions turn out to be as the field continues to advance!
Posted in In The News | Tagged focused libraries, fragment-based screening, High-Throughput Screening | Leave a Comment »
In the spirit of holiday giving, this year we decided to Adopt a family for the holidays!
Our family has three children: Annalisa (age 3), Amari (age 2), and Mario (8 months). Their mother requested items such as pajamas, warm weather clothing, toys, and books.
BIOCIUS employees were very generous, either employees shopped for items, or donated money, and Scientist Michelle Romm did the rest of the shopping!
We have much to be thankful for as a company this holiday season, and are happy to share our blessings with those less fortunate in the community!
HAPPY HOLIDAYS!
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BIOCIUS Life Sciences forms Independent Operating Company
RapidFire® Business Unit completes strategic spin‐out from BioTrove Inc.
Woburn, MA. December 16, 2009. BIOCIUS Life Sciences announced today that it has completed its spin‐out from BioTrove Inc. and is an independent operating company. BIOCIUS Life Sciences holds all of the RapidFire® intellectual property and technology; most importantly every employee of the former BioTrove RapidFire business unit is now a member of BIOCIUS Life Sciences.
BIOCIUS is supported by a syndicate of investors that includes Catalyst Health Ventures, Excel Venture Management, Fletcher‐Spaght, CB Health Ventures, Vox Equity Partners, Echelon Ventures and BioFrontier Partners. Led by Chairman and Chief Executive Officer Jeffrey Leathe, the BIOCIUS team of experienced scientists and engineers will now be able to focus their resources on the RapidFire product line as well as new research and development projects committed to eliminating bottlenecks in drug discovery for their clients and collaborators. According to Mr. Leathe, “BIOCIUS is well capitalized and we plan to maximize on our strengths in drug discovery products and services to aggressively expand our portfolio and add value to our many collaborators in the pharma and biotech community. The current and future customer base will benefit from the shared vision and innovative solutions of our expansive pipeline.”
Joining Mr. Leathe, are corporate officers Dr. Can ‘Jon’ Özbal, COO and Mr. Gary St. Pierre, CFO who will lead an experienced executive team with a history of success in the biotech and pharmaceutical market. Building on a breakout year in 2009 for sales of RapidFire instruments and services, BIOCIUS plans to continue its concentration on the application areas of in vitro ADME and lead discovery, with its industry‐leading, label‐free platform. According to Dr. Can ‘Jon’ Özbal, “new products in the pipeline will both enhance the workflows of our existing pharma and biotech customers, and allow us to expand that customer base with technologies also suited to our clients at academic and government institutions.”
About RapidFire® Technology
RapidFire mass spectrometry greatly decreases the bottlenecks that occur during drug discovery. By enabling automated sample preparation at a rate of up to six seconds per sample and integrating seamlessly to the mass spectrometer, RapidFire enhances high‐throughput screening of candidate drug compounds and in vitro ADME assays. RapidFire allows for the analysis of a wide range of otherwise intractable targets such as triglycerides, lipids, fatty acids, prostaglandins, steroids, coenzyme A derivatives, neurotransmitters, epigenetic targets, anti‐fungals and anti‐infectives, which are difficult to study using traditional methods such as fluorescence or radiolabels. RapidFire hardware is available as a solution in our collaborators laboratories or as a contract research service in the BIOCIUS laboratory.
About BIOCIUS Life Sciences, Inc.
Named from the Greek word “BIO” (life) and the Latin word “OCIUS” (faster), BIOCIUS Life Sciences, provides the biopharmaceutical industry with faster answers: Products and services committed to speed and accuracy in drug discovery. Used by 13 of the top 15 pharmaceutical companies, BIOCIUS’s products and contract research services enable our partners to exceed their business goals.
Contact:
Jennifer M. Rossi, PhD
Director of Marketing & Corporate Communications
781.721.3679
jrossi@BIOCIUS.com
Posted in In The News | Leave a Comment »
A normal day in the BIOCIUS lab- team members Nik Parikh (foreground), Peter Rye and Lauren Frick are setting up reaction plates to investigate enzyme kinetics and CYP450 Inhibition.
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Mike Biros of BIOCIUS Life Sciences will be presenting at the LRIG Bay Area event: Integrating New Automation Tools into the Laboratory Workflow. www.LRIGBayarea.org
The event will be held on December 1st, at the Embassy Suites Hotels, South San Francisco, CA.
Mike’s presentation will be given at 6:20 p.m. and an abstract of the event is as follows:
“An integrated, automated system for high-throughput ADME sample analysis to enhance laboratory workflows”
Efficient and robust in vitro ADME assay screening is essential for early drug candidate optimization. Mass spectrometry (MS) has emerged as the preferred method to address the multi-dimensional challenge toward compound selection on account of its sensitivity, selectivity, and label-free rationale. However, a daunting shortcoming of MS is its low throughput: Traditional MS approaches require time-consuming off-line sample preparation and liquid chromatography (LC) separation. In contrast, the RapidFire 300 draws on MS-based data quality without conceding speed and integrates easily into existing laboratory workflows. At its core, the RapidFire 300 platform consists of a fast, serial, solid-phase extraction (SPE) sample purification system, interfaced to an atmospheric phase ionization (API) MS.Automated sampling of analytes is achieved using a plate handler with a barcode scanner that can accommodate 96-well or 384-well plate formats. Samples are aspirated and delivered to an on-line SPE cartridge for purification Analytes of interest are retained on the cartridge, washed, and eluted. The eluted analytes are delivered to a triple quadrupole (QqQ) or time-of-flight (TOF) MS for ionization and mass detection. A single sample can be purified, delivered, and detected by the mass spectrometer in 6-10 seconds Intricate software communication between the RapidFire 300 sample preparation platform and the MS detection device complement their hardware features to render automated, unattended operation for up to 24 hours. Loading of a single protocol setup through a flexible user’s interface launches the screening of a series of sequences, each with separate customized plate maps, RapidFire analytical conditions and MS detection parameters, as dictated by the user’s initial input. Quantitative data analysis ensues automatically, with visually driven quality control steps. The enhanced automation of the RapidFire 300 and its integration with the downstream MS expand the range of in vitro ADME investigations supported by the technology. Not only does it apply to CYP 450 drug-drug interaction and induction studies, but it can also tackle assays that involve distinct methods for sequentially-fed sample series, such as metabolic stability, permeability (Caco-2, PAMPA), plasma protein binding, and solubility/lipophilicity. This novel automated SPE-MS technology integrates into the work flow of standard HTS laboratories streamlining and enabling an array of HTS and in vitro ADME studies. Thus, the RapidFire platform provides an innovative solution for label-free screening in high-throughput drug discovery and development applications.
Check out the event and post comments on the presentation below!
Posted in Events | Tagged ADME, Caco-2, Mass Spectrometry, PAMPA, RapidFire 300, time-of-flight | Leave a Comment »
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- check out the interesting article in JBS written by Dan Kassel. http://jbx.sagepub.com/cgi/content/abstract/1087057110362581v1?papetoc” 3 days ago
- Missed our Webinar? BIOCIUS will Re-Broadcast on March 16th at 9 AM! Register nowat: https://www1.gotomeeting.com/register/717139513 1 week ago
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